Pep Guardiola confirmed that Kevin De Bruyne will miss out on crunch matches against Liverpool and Tottenham Hotspur. He is ruled out for 4-6 weeks after picking up a hamstring injury after the match against Brighton and Hove Albion. He recently hit the milestone of picking up 100 assists and has joined the top 10 players with the highest amount of assists and sits at joint 10th with Teddy Sheringham.
Sergio Aguero and Kevin De Bruyne will be missing for Manchester City at the same time
Sergio Aguero will be missing the next two weeks for Manchester City after having tested positive for COVID-19 after coming in contact with a positive case before. He will be required to self-isolate for two weeks and then return a negative test to play for the team again. In this two weeks he will about 4 matches and may be back for the match against Liverpool. Kevin De Bruyne is expected to miss matches until Manchester City plays Arsenal 4 weeks from now if things go well for him and in the case that his injury keeps him out for 6 weeks, the Manchester Derby is the time he can return.
Manchester City has coped without him before and have won the Premier League in the 2017/18 season and it is expected that they can cope now too. In this time period much will be expected of Phil Foden and he would have to step up to be a creative player for them.