Cardinals Suffer Hilarious Meltdown in All-Time Collapse vs. Titans – “Goofiest Way to Lose a Game”
The Arizona Cardinals committed 8 penalties for 47 yards. They were flagged a total of 11 times.

Kyler Murray (Image via IMAGO)
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Epic collapses in football seem to be the latest trend, as fans witnessed two in the space of a couple of hours on Sunday night. The Miami Dolphins lost despite leading by 17 points, while the Arizona Cardinals bizarrely lost to the worst team in football, the Tennessee Titans, while leading by 15 after halftime.
Quarterback Kyler Murray orchestrated three rushing touchdowns on either side of the first two quarters to make life difficult for the visitors. Michael Carter scored with a 1-yard run, followed by Murray’s 12-yard scamper, before Zonovan Knight bulldozed his way into the Titans’ end zone from 1 yard.
Tennessee kicker Joey Slye’s two field goal completions from 44 and 51 yards kept his team in the hunt. The Titans waited for a signal to start their comeback, and it appeared three minutes into the fourth quarter.
Emari Demercado raced past the Titans’ d-line for a home call, but the dynamic running back slowed down, which allowed L’Jarius Sneed to catch up to him. However, Sneed’s presence wasn’t required, as Demercado released the ball before reaching the goal.
#Cardinals HC Jonathan Gannon was livid — the most I’ve ever seen him — after Emari Demercado fumbled before crossing the goal line for a touchback. pic.twitter.com/g4KQaWijpZ https://t.co/rv15csrGMq
— Ari Meirov (@MySportsUpdate) October 6, 2025
A switch flipped in the Titans. All of a sudden, they went from a disgruntled unit to a well-drilled squad. Arizona helped them as well.
The Arizona Cardinals just suffered perhaps the most hilarious loss in NFL history
— NFL Memes (@NFL_Memes) October 5, 2025
– 21-6 4th quarter lead
– Fumbled crossing the goal line to go up 28-6
– Fumbled an interception for a touchdown up 21-12 with less than 5 minutes left pic.twitter.com/d6tgK0nCXt
The Cardinals’ comedy of errors paved the way for an unlikely Titans comeback
Jonathan Gannon’s Cardinals were coming off two straight losses against divisional opponents. This made the Titans fixture all the more crucial for the NFC West franchise in its attempt to save its season.

Unfortunately, luck didn’t favor the Cardinals. Tony Pollard’s touchdown run shifted the lead to Tennessee, but an unusual sequence four minutes before the end completely changed the outcome.
Rookie Titans quarterback Cam Ward overthrew a pass straight to Cardinals’ Dadrion Taylor-Demerson, which he failed to keep under control. The ball slipped out and then pinballed its way into the end zone before veteran WR Tyler Lockett made sure to pounce on it before it went out of bounds. It was given as a Tennessee touchdown.
One of the craziest touchdowns you will ever see.
— Dov Kleiman (@NFL_DovKleiman) October 5, 2025
Cam Ward just threw an interception that resulted in a touchdown for the Titans.
How is this real life?? 🤯🤯pic.twitter.com/JzAMkXvkpc
In the final drive of the game, Ward led his team 71 yards inside enemy territory to present Slye with the chance to seal the victory. He smashed a field goal from 29 yards before the clock hit zero and won the Titans’ first game of the season 22-21.
that’s the goofiest way to lose a game I have ever seen. film room gonna be goooooooooood
— Kai (@sssushicat) October 6, 2025
Titans fans thanking Kyler Murray for their first win pic.twitter.com/IDKr1iQ4zp
— Pardon My Take (@PardonMyTake) October 5, 2025
The Arizona Cardinals pay Kyler Murray over 40 million dollars a year, drafted Marvin Harrison Jr 4th overall and have the 2nd highest paid TE in the NFL and called 3 straight runs with practice squad RB’s needing just one first down to win the game. pic.twitter.com/ZHo23S01kM
— K1SinceDay1 (@KSzn2021) October 6, 2025
Kyler Murray got injured by taking a ball to the face pic.twitter.com/HCssnNE8lD
— Pardon My Take (@PardonMyTake) October 5, 2025
Cam Ward to Kyler Murray pic.twitter.com/2ExasYinTV
— Simpsons NFL (@TheSimpsonsNFL) October 5, 2025
If I own the Arizona Cardinals I don't wait until tomorrow morning. I fire their Head Coach (Jonathan Gannon) immediately for his ultra conservative play calling on their last possession & release running their back (Emari Demercado) for this INEXCUSABLE play#Cardinals pic.twitter.com/6fRf4NhKoQ
— The Win Doctor (@Windoctorx) October 5, 2025
Murray and the Arizona Cardinals became the first team since the 1970 AFL-NFL merger to lose three straight games on game-winning field goals.
Murray finished with 23 completions from 31 attempts for 220 yards, 4 carries for 25 yards, and 1 rushing touchdown.
I don’t really know what to think about that. I don’t even know. I really don’t even know. That’s ‘How to Lose a Game 101.’ I don’t know. It was crazy.
Kyler Murray said after the game (H/T: ESPN)
Kyler Murray was asked about the cardinals offense not playing to win at the end and not being able to use his arm to get the game wining first down👀
— K1SinceDay1 (@KSzn2021) October 6, 2025
He’s CLEARLY upset with the playcalling and decision to be conservative. Deserves to be frustrated🤬 pic.twitter.com/8EyV05XUki
There’s still a lot of football left to be played. At present, the Cardinals sit at the bottom of the West with a 2-3 record. They are on the road in Week 6 to face off against the 4-1 Indianapolis Colts.
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