Monday Night Football Week 12: Where and How to Watch Carolina Panthers vs. San Francisco 49ers, Live Stream, and Broadcast Details⁩

Brock Purdy is set to play in his first-ever game against the Carolina Panthers, a week after replacing Mac Jones as the San Francisco 49ers’ starting quarterback. Both teams secured wins in their last games.

The Niners came away with a 41-22 victory over the Arizona Cardinals at Glendale in Week 11. Purdy threw 3 touchdown passes and 200 passing yards and finished with a passer rating of 133.5. Christian McCaffrey rushed for 81 yards on 13 carries, scored 2 rushing touchdowns, recorded 5 catches for 40 yards, and 1 receiving touchdown. Tight end George Kittle caught 6 passes for 67 yards and scored 2 touchdowns.

Bryce Young made history for the Panthers in their overtime 30-27 victory over the Atlanta Falcons. The former number one overall pick threw 448 yards, surpassing Cam Newton as the Panthers’ single game passing yards leader, 3 touchdowns, and 123.2 passer rating. Rookie receiver Tetairoa McMillan caught 8 passes for 130 yards and scored 2 touchdowns, while Xavier Legette caught 4 for 83 yards and 1 score.

The Panthers are among the few teams that boast a winning record against the 49ers. In their 23 previous matchups, the Panthers hold a 13-10 record, but they’ve lost both of their most recent two games (conceded an average of 40 points).

When and what time is the Week 12 clash between the Carolina Panthers and San Francisco 49ers at?

• Game: Carolina Panthers vs. San Francisco 49ers
• Date: Monday, November 24
• Time: 8:15 p.m. ET
• Venue: Levi’s Stadium in Santa Clara, California

The Week 12 clash between the Carolina Panthers and the San Francisco 49ers is set to take place at 8:15 p.m. ET on Monday, November 24, at Levi’s Stadium in Santa Clara, California

What channel can one watch the Week 12 clash between the Carolina Panthers and San Francisco 49ers on?

• Game: Carolina Panthers vs. San Francisco 49ers
• Date: Monday, November 24
• Where to watch/Channel: ESPN
• Announcers: Joe Buck, Troy Aikman, Laura Rutledge and Lisa Salters
• Raido: KSFO (810 AM), The Bone (107.7 FM), and the 49ers Radio Network

What are the livestreaming options for the Week 12 clash between the Carolina Panthers and San Francisco 49ers?

Watch local and primetime regular-season games on your phone or tablet on NFL+, DAZN and FUBO TV.

What are the odds for the Week 12 fixture between the Carolina Panthers and San Francisco 49ers?

According to FanDuel Sportsbook, the San Francisco 49ers are the favorites to defeat the Carolina Panthers in Week 12.

• Panthers +7 (-110)
• 49ers -7 (-110)

Moneyline

• Panthers +275
• 49ers -340

Total

• OVER 48.5 (-105)
• UNDER 48.5 (-115)

Predicted lineups for the Week 12 fixture between the Carolina Panthers and the San Francisco 49ers

Carolina Panthers

Bryce Young, Chuba Hubbard, Rico Dowdle, Trevor Etienne, Jalen Coker, Tommy Tremble, Xavier Legette, Tetairoa McMillan, Mitchell Evans, Ja’Tavion Sanders, Tre’von Moehrig, Christian Rozeboom, Corey Thornton, Jaycee Horn, Claudin Cherelus, Nick Scott, Mike Jackson, Princely Umanmielen, and Tershawn Wharton

San Francisco 49ers

Brock Purdy, Christian McCaffrey, Jauan Jennings, George Kittle, Ricky Pearsall, Kendrick Bourne, Jake Tonges, Kyle Juszczyk, Trent Williams, Connor Colby, Jake Brendel, Dominick Puni, Colton McKivitz, Bryce Huff, Kalia Davis, Jordan Elliott, Mykel Williams, Dee Winters, Luke Gifford, Renardo Green, Marques Sigle, Jason Pinnock, Deommodore Lenoir, and Upton Stout

Why can the Panthers win?

Quarterback Bryce Young has missed just one game in 2025. After 10 starts, Young has put up 1,962 passing yards, with 14 touchdowns against 7 interceptions. Rico Dowdle has racked up 833 total rushing yards and 5 touchdowns. McMillan has 54 catches (4.9 receptions per game on 8.1 targets per game) for 748 yards and 4 receiving touchdowns.

Why can the 49ers win?

Purdy will start for the Niners on MNF. So far, he has racked up 786 passing yards, 7 touchdowns, and 4 interceptions. McCaffrey is in incredible form, racking up 707 yards and 6 touchdowns (64.3 yards per game) along with 74 catches (6.7 per game) for 732 yards (66.5 per game) and 5 touchdowns. Jauan Jennings leads the receivers with 378 receiving yards and 3 touchdowns on 32 receptions.

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