Thursday Night Football Week 5: Where and How to Watch San Francisco 49ers vs. Los Angeles Rams, Live Stream, and Broadcast Details

The Los Angeles Rams (3-1) and San Francisco 49ers (3-1) will face off this week at SoFi Stadium in Inglewood, California, their home field. The two teams will battle it out in the humid Southern Los Angeles for the top spot in the NFC West.

The Rams and the 49ers both have three wins in the season. The Rams defeated the Houston Texans, the Tennessee Titans, and the Indianapolis Colts. The 49ers defeated the two other division rivals Arizona Cardinals and Seattle Seahawks, as well as secured a win over the New Orleans Saints. The Niners lost against the Jacksonville Jaguars in Week 4 after a 3-0 start, while the Philadelphia Eagles came back after a deficit to thrash the Rams.

As division rivals, the two franchises have played each other over 152 times in the league’s history, including two postseason games. The 49ers have the lead with 78 wins, but the Rams had the last laugh in the previous three games. The Rams swept the division series last season in two close-contested matchups.

In 2022, they faced each other in the NFC Championship game. The Rams defeated the Niners 17-20 at the SoFi Stadium and went on to win the Super Bowl. As they face each other on Thursday, the Rams will hope to extend their winning streak while the 49ers will look to end the drought.

What time is the NFL Week 5 TNF between the San Francisco 49ers and the Los Angeles Rams?

• Game: San Francisco 49ers @ Los Angeles Rams
• Day: Thursday, October 2
• Time: 8:15 p.m. ET
• Venue: SoFi Stadium, Inglewood, California

The NFL week 5 fixture between the San Francisco 49ers and Los Angeles Rams will be played at 8:15 p.m. ET on Thursday, October 2, at the SoFi Stadium.

Where can one watch the San Francisco 49ers vs. Los Angeles Rams game?

• Game: San Francisco 49ers @ Los Angeles Rams
• Day: Thursday, October 2
• Where to Watch: FOX
• Announcers: Al Michaels, Kirk Herbstreit, Kaylee Hartung

What are the livestreaming options for the game?

Fans can watch local and primetime regular-season games on their phone or tablet through FuboTV, DAZN, and Peacock.

Betting Odds for NFL Week 5 TNF

According to BetMGM Sportsbook, the Los Angeles Rams are more likely to finish on top on Thursday with an edge of -5.5 in the spread.

• Spread favorite: Rams (-5.5)
• Moneyline: Rams (-250), 49ers (+200)
• Total: 47 points

Predicted Lineups for San Francisco 49ers and Los Angeles Rams on Thursday

San Francisco 49ers

Brock Purdy, Christian McCaffrey, Demarcus Robinson, Ricky Pearsall, Kendrick Bourne, Jake Tonges, Kyle Juszczyk, Trent Williams, Connor Colby, Jake Brendel, Dominick Puni, Colton McKivitz, Bryce Huff, Kalia Davis, Jordan Elliott, Mykel Williams, Dee Winters, Fred Warner, Luke Gifford, Renardo Green, Marques Sigle, Jason Pinnock, Deommodore Lenoir, and Upton Stout.

Los Angeles Rams

Matthew Stafford, Kyren Williams, Puka Nacua, Davante Adams, Jordan Whittington, Tyler Higbee, Alaric Jackson, Steve Avila, Coleman Shelton, Kevin Dotson, Rob Havenstein, Braden Fiske, Poona Ford, Kobie Turner, Byron Young, Nate Landman, Omar Speights, Jared Verse, Kam Curl, Cobie Durant, Kamren Kinchens, Emmanuel Forbes Jr, and Quentin Lake.

Why can the San Francisco 49ers win?

The San Francisco 49ers are quite the underdogs in the game. The Niners will look forward to capitalizing on the impact that Christian McCaffrey can provide. The Niners have been pretty good with the Rams coming off a loss.

In 2021, the 49ers had lost all five of their previous games and had a 3-5 record before playing the Rams. It was Week 10, and the 49ers railroaded the Rams 31-10 in a crucial do-or-die game.

The 49ers facing the Rams following a loss since 2019:

2019: 34-31 win after loss to Atlanta

2020: 23-20 win after loss to New Orleans

2021: 31-10 win after loss to Arizona

2022: 24-9 win after loss to Denver & 31-14 win after loss to KC

— Jason Aponte (@JasonAponte2103) September 29, 2025

Why Los Angeles Rams can win the TNF duel?

The Rams’ defense is one of the best in the league so far, allowing just 81 points. Meanwhile, in terms of offense, the Rams are fourth in the league in offense with 388.3 yards per game. They are third in passing offense while being the few teams with more than 100 points in four games. Puka Nacua, one of their key wideouts, leads the league in receiving yards with 503 yards.

The Rams can capitalize on the Niners’ recent struggles, particularly their inconsistency in the run game and inefficiency in the red zone. They converted just one of three trips into touchdowns. On defense, San Francisco has ended up giving away big plays, exihibted sloppy tackling, and costly penalties that negate turnovers. These are opportunities that the Rams can exploit to gain momentum and control the matchup.

More so than the Rams’ capabilities, the 49ers’ drawbacks might hand the Rams an easy win on Thursday. The 49ers’ starting quarterback, Brock Purdy, was confirmed to be questionable for the upcoming duel. Though the 49ers are optimistic, he’s still healing from the turf toe injury he suffered in Week 1. The quarterback’s struggles in the Jaguars game were also evident; however, it cannot be attributed to the injury without any proof.

In addition to Purdy, the team is also pretty banged up with injuries on both sides of the ball. Ricky Pearsall, who came back from injuries, was once again targeted in the Jags game and will be questionable. The situation with Jauan Jennings is also similarly bad.

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